#BookReview: Life As We Made It by Beth Shapiro

Solid History, Perhaps A Bit Too Optimistic On Future Tech. In showing the history of how humans have been using crude genetic engineering essentially since we first began interacting with the world – both plant and animal – and in showing how our more modern techniques – including CRSPR – came to be, Shapiro does a great job in showing just how much humans have *already* shaped the evolution of non-human life on this planet. In the ancient world, she uses a lot of her own experiences as a scientist in that exact field, and even in the more modern cases she is discussing techniques she mentions in the earlier sections as having used extensively. On these points, Shapiro is truly excellent.

Where she stumbles a bit – not enough for a star deduction, but enough for a bit of commentary – is that she is perhaps a bit too optimistic about how genetic tinkering will be used in the future. Yes, she discusses the various quandaries, but even in such discussions- *even when discussing the GMO humans created in China a couple of years ago* – Shapiro tends to just hand wave over the negative, darker sides of the technology even while acknowledging their potentially cataclysmic power. This is where a solid dose of science fiction is useful, showing that even when scientists such as Shapiro have the best of intentions… things may not always turn out the way they think, and thus caution truly is warranted. (Yes, I’m thinking of a specific book in this particular example, but the reveal that GMO is used within it is a *massive* spoiler, and thus I’m not naming it here. I *will* note that it is by the same author and indeed part of the spoiler is that it uses some of the same tech as described in HUNGER by Jeremy Robinson, which is another cautionary tale of the “benefits” of genetic modification.)

Still, for what it is and for what the description claims it sets out to do, this truly is a solid examination of the history and current state of the field, and for this it is very much recommended.

This review of Life As We Made It by Beth Shapiro was originally written on September 10, 2021.

#BookReview: You Bet Your Life by Paul A Offit

Startling Look At (Mostly Relatively Recent) Medical History. I consider myself a fairly well-read guy who is fairly knowledgeable about a *very* wide range of topics. Here, Offit shares stories of medical breakthroughs – including several which are now literally every day occurrences – and how the initial days of these breakthroughs weren’t always so routine. Indeed, many of the stories Offit shares about these breakthroughs – some of which were still being litigated within the last decade – are quite horrific, both from the practitioners really not understanding what they were doing and in some cases when they *did* know what they were doing – and did it anyway. Including one tale in particular about the (now) famous Jonas Salk himself that was quite disturbing to read. In the end, the book does exactly what it sets out to do – shows that there is always inherent risk in any medical procedure, particularly novel ones, and that often times it is those whose lives will be cut short with or without the procedure that take the risks that ultimately reduce those risks for later people and indeed enhance the lives of people they will never know many years down the line. And yes, all of this is wrapped around the current debate over the COVID-19 vaccines – though while these are discussed, they are not actually a core component of the text itself. The discussion here is current circa early November 2020 and is slightly outdated even as I read the text in early February 2021 – and certainly will have advanced even further by the time of the book’s actual publication in mid September 2021. Ultimately a truly fascinating read that is equally disturbing and enlightening, this book is very much recommended.

This review of You Bet Your Life by Paul A Offit was originally written on February 8, 2021.